Interaction of [Rh2(O2CCH3)4(H2O)2] and [Rh2(O2CCH(OH)Ph)2(phen)2(H2O)2](O2C-CH(OH)Ph)2 With Sulfhydryl Compounds and Ceruloplasmin

摘要

The interaction of binuclear rhodium(II) complexes [Rh2(OOCCH3)4(H2O)2], [Rh2{OOCCH(OH)Ph}2(phen)2(H2O)2] {OOCCH(OH)Ph}2, [Rh2(OOCCH3)2(bpy)2(H2O)2](OOCCH3)2 and [Rh2Cl2(OOCMe)2(bpy)2](3H2O) with ceruloplasmin, cysteine, glutathione and coenzyme A have beeninvestigated using. UV-Vis and CD spectroscopies. The complexes containing phen or bpy at pH = 7.4 and4.0 are readily reduced with sulfhydryl compounds, while rhodium(II) acetate is relatively stable in theseconditions. Complex [Rh2{OOCCH(OH)Ph}2(phen)2(H2O)2] strongly changes structure of ceruloplasminleading to the decrease of of α-helix content and loss of oxidase activity.